Motif ID: FOX{D1,D2}.p2

Z-value: 1.655


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD1chr5_-_727801070.665.4e-03Click!
FOXD2chr1_+_476742750.116.7e-01Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_21084077 3.071 APOB
apolipoprotein B (including Ag(x) antigen)
chr5_+_78568094 2.980


chr5_+_78567604 2.905 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr10_+_63478974 2.847 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr1_+_144149794 2.714 NM_006472
TXNIP
thioredoxin interacting protein
chr20_-_45410033 2.655 ZMYND8
zinc finger, MYND-type containing 8
chr7_+_106596641 2.559 NM_012257
HBP1
HMG-box transcription factor 1
chr2_-_21084911 2.333 APOB
apolipoprotein B (including Ag(x) antigen)
chr7_+_134483305 2.305 NM_018295
TMEM140
transmembrane protein 140
chr19_+_18357966 2.248 NM_004864
GDF15
growth differentiation factor 15
chr19_+_1158129 2.099 EFNA2
ephrin-A2
chr13_+_96672705 1.903 MBNL2
muscleblind-like 2 (Drosophila)
chr1_+_196392513 1.829 NM_133494
NEK7
NIMA (never in mitosis gene a)-related kinase 7
chr14_+_31868229 1.803 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr20_+_254205 1.792 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr5_+_90711887 1.739 LOC100129716
hypothetical LOC100129716
chr2_+_96845704 1.718 NM_017623
NM_199078
CNNM3

cyclin M3

chr6_+_64403631 1.705 PHF3
PHD finger protein 3
chr6_+_64403685 1.691 PHF3
PHD finger protein 3
chr1_-_177378801 1.676 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr6_+_64403936 1.665 PHF3
PHD finger protein 3
chr4_+_140806536 1.643 MGST2
microsomal glutathione S-transferase 2
chr6_+_64403668 1.577 PHF3
PHD finger protein 3
chr12_+_105220638 1.555 NM_152772
TCP11L2
t-complex 11 (mouse)-like 2
chr3_+_180348818 1.544 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr3_-_15814678 1.480 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr6_+_64414389 1.480 NM_015153
PHF3
PHD finger protein 3
chr20_+_2030527 1.458 NM_080836
STK35
serine/threonine kinase 35
chr10_+_111959978 1.439 NM_001008541
MXI1
MAX interactor 1
chr20_+_2031418 1.369 STK35
serine/threonine kinase 35
chr4_+_140806371 1.364 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr16_-_46957284 1.285 NM_001006610
SIAH1
seven in absentia homolog 1 (Drosophila)
chr20_+_62357490 1.282 NM_001104925
NM_018257
PCMTD2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr2_+_86800940 1.271 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr17_+_69939130 1.259 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr6_+_17708483 1.251 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr3_+_23962518 1.234 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr16_-_46957254 1.233 SIAH1
seven in absentia homolog 1 (Drosophila)
chr3_-_71196696 1.231 FOXP1
forkhead box P1
chr7_+_91408086 1.231 NM_005751
NM_147185
AKAP9

A kinase (PRKA) anchor protein (yotiao) 9

chr2_+_86800898 1.229 NM_022780
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr20_+_21054623 1.227 NM_001163022
NM_001163023
NM_018474
PLK1S1


polo-like kinase 1 substrate 1


chr8_-_29263714 1.199 NM_001394
DUSP4
dual specificity phosphatase 4
chr15_+_22781292 1.196 PAR5
Prader-Willi/Angelman syndrome-5
chr2_+_44249487 1.180 NM_001033556
NM_001033557
NM_002706
NM_177968
NM_177969
PPM1B




protein phosphatase, Mg2+/Mn2+ dependent, 1B




chr2_+_86801081 1.174 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr3_-_188935363 1.174 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr2_-_69033515 1.165 NM_182536
GKN2
gastrokine 2
chr17_+_57909979 1.148 NM_001112707
NM_006852
TLK2

tousled-like kinase 2

chr2_+_44249565 1.133 PPM1B
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr5_+_149845503 1.125 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr1_+_33494745 1.108 NM_152493
ZNF362
zinc finger protein 362
chr3_-_71376919 1.105 FOXP1
forkhead box P1
chr3_+_23961739 1.098 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr20_-_42561725 1.072


chr6_+_112481970 1.044 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr6_+_12120709 1.043 NM_002114
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chr10_+_31650069 1.025 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr10_+_82163568 1.022 C10orf58
chromosome 10 open reading frame 58
chr11_-_10630408 1.016 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr14_+_22136968 1.014 NM_022060
ABHD4
abhydrolase domain containing 4
chr18_+_58533597 1.003 NM_194449
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1
chr6_-_159386007 0.995 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr15_-_75135496 0.979 TSPAN3
tetraspanin 3
chr10_+_63331018 0.978 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr10_-_44794146 0.968 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr6_+_139136349 0.962 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr11_+_20005704 0.951 NAV2
neuron navigator 2
chr8_+_100025806 0.948 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr6_+_134800533 0.939 LOC154092
hypothetical LOC154092
chr6_-_56824371 0.931 DST
dystonin
chr11_+_101723125 0.927 BIRC2
baculoviral IAP repeat containing 2
chr2_-_65447370 0.922 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr6_-_27988152 0.917 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr1_-_159459814 0.888 APOA2
apolipoprotein A-II
chr2_-_160181206 0.886 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr2_+_65136989 0.877 NM_015147
CEP68
centrosomal protein 68kDa
chr9_+_132990760 0.874 NM_005085
NUP214
nucleoporin 214kDa
chr12_-_52281050 0.873 NM_001130059
ATF7
activating transcription factor 7
chr7_+_107171514 0.872 NM_024814
CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr2_+_151974630 0.864 NM_001177663
NM_018151
NM_001177664
RIF1


RAP1 interacting factor homolog (yeast)


chr20_+_56397568 0.862 NM_001195677
NM_004738
VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C

chr1_+_24518398 0.854 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr15_+_97009194 0.852 IGF1R
insulin-like growth factor 1 receptor
chr2_+_149119029 0.842 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_-_162808123 0.836 NM_004460
FAP
fibroblast activation protein, alpha
chr2_-_65447267 0.833 SPRED2
sprouty-related, EVH1 domain containing 2
chr2_-_213724577 0.829 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr5_+_27508139 0.825 LOC643401
hypothetical protein LOC643401
chr6_-_33276131 0.821 RXRB
retinoid X receptor, beta
chr14_+_59785723 0.813 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr3_+_64645819 0.812 LOC100507098
hypothetical LOC100507098
chr8_-_86441115 0.811 NM_001164830
CA1
carbonic anhydrase I
chr1_+_24518501 0.806 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr21_+_29593607 0.796 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr6_-_42124587 0.795 NM_001136017
NM_001136126
CCND3

cyclin D3

chr5_+_65258316 0.795 ERBB2IP
erbb2 interacting protein
chr5_+_162865128 0.795 NM_013283
MAT2B
methionine adenosyltransferase II, beta
chr2_-_138975682 0.783


chr10_+_18729518 0.771 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr11_-_56846246 0.763 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr17_+_36642240 0.760 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr16_-_4836198 0.756 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr1_-_180624494 0.755 GLUL
glutamate-ammonia ligase
chr14_+_59785739 0.753 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr5_+_72287625 0.752


chr20_+_56904042 0.744 GNAS
GNAS complex locus
chr4_-_152368492 0.742 SH3D19
SH3 domain containing 19
chr6_-_33276347 0.742 NM_021976
RXRB
retinoid X receptor, beta
chr7_-_99536214 0.728 NM_182776
MCM7
minichromosome maintenance complex component 7
chr2_-_192419896 0.728 SDPR
serum deprivation response
chr21_+_29439768 0.726 C21orf7
chromosome 21 open reading frame 7
chr2_+_196230096 0.717 NM_020342
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr13_+_75232797 0.716 NM_015842
LMO7
LIM domain 7
chr3_+_23904086 0.710 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr1_-_180624380 0.702 GLUL
glutamate-ammonia ligase
chr7_-_155129817 0.701


chr6_-_33276141 0.700 RXRB
retinoid X receptor, beta
chr16_-_3362283 0.691 NM_001190476
MTRNR2L4
MT-RNR2-like 4
chr6_+_155579788 0.691 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr14_+_23937766 0.690 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr5_+_72287630 0.688 FCHO2
FCH domain only 2
chr5_+_137701852 0.686 FAM53C
family with sequence similarity 53, member C
chr5_+_137701855 0.679 FAM53C
family with sequence similarity 53, member C
chr1_-_150564302 0.679 NM_002016
FLG
filaggrin
chr2_+_172658453 0.676 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr5_+_72287509 0.675 NM_001146032
NM_138782
FCHO2

FCH domain only 2

chr5_-_16561936 0.675 NM_019000
FAM134B
family with sequence similarity 134, member B
chr19_+_1157462 0.673 STK11
serine/threonine kinase 11
chr14_+_101346032 0.669 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr14_+_59786047 0.669 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr20_-_33705244 0.663 NM_003915
CPNE1
copine I
chr20_+_43943254 0.663 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr2_-_192420168 0.662 NM_004657
SDPR
serum deprivation response
chr2_-_189752575 0.654 NM_000393
COL5A2
collagen, type V, alpha 2
chr7_-_112366962 0.651 NM_152556
C7orf60
chromosome 7 open reading frame 60
chr1_-_159459999 0.645 NM_001643
APOA2
apolipoprotein A-II
chr14_+_101345878 0.645 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr1_+_225194582 0.643 ADCK3
aarF domain containing kinase 3
chr1_+_225194616 0.632 ADCK3
aarF domain containing kinase 3
chr8_-_28299850 0.630 NM_018660
ZNF395
zinc finger protein 395
chr1_+_87567164 0.627 LMO4
LIM domain only 4
chr17_+_64922420 0.625 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr16_+_73590419 0.619 ZNRF1
zinc and ring finger 1
chr4_+_124537334 0.617 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_+_225194560 0.616 NM_020247
ADCK3
aarF domain containing kinase 3
chr14_+_23654307 0.604 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr1_+_225194622 0.601 ADCK3
aarF domain containing kinase 3
chrX_+_146801355 0.599


chr1_+_150753601 0.594 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr18_+_64616296 0.593 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr2_+_68815416 0.592 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr10_-_21226536 0.589 NM_006393
NEBL
nebulette
chr3_+_115099007 0.585 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr2_+_151974849 0.585 NM_001177665
RIF1
RAP1 interacting factor homolog (yeast)
chr2_+_196229715 0.582 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr7_+_155129904 0.580 RBM33
RNA binding motif protein 33
chr2_-_128358903 0.577 NM_031445
AMMECR1L
AMME chromosomal region gene 1-like
chr6_-_42124361 0.576 CCND3
cyclin D3
chr11_-_5247948 0.576 NM_005330
HBE1
hemoglobin, epsilon 1
chr3_+_69895310 0.576 NM_001184967
MITF
microphthalmia-associated transcription factor
chr4_+_95595419 0.574 PDLIM5
PDZ and LIM domain 5
chr2_+_61258263 0.571 AHSA2
AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr2_+_170149092 0.571 NM_004792
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr6_+_12398514 0.569 NM_001168319
NM_001955
EDN1

endothelin 1

chr8_+_70567581 0.564 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr17_-_36719030 0.562 NM_001146182
KRTAP16-1
keratin associated protein 16-1
chr2_+_201689174 0.556 CFLAR
CASP8 and FADD-like apoptosis regulator
chr2_-_101457596 0.556 NM_001145664
RFX8
regulatory factor X, 8
chr14_-_34414603 0.547 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr1_+_87567136 0.546 LMO4
LIM domain only 4
chr17_+_36665161 0.542 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr19_-_42880184 0.541 ZNF607
zinc finger protein 607
chr12_+_100198026 0.540 NM_014503
UTP20
UTP20, small subunit (SSU) processome component, homolog (yeast)
chr2_+_198089036 0.539 MOBKL3
MOB1, Mps One Binder kinase activator-like 3 (yeast)
chr17_+_54652609 0.529 NM_001165993
NM_001165994
NM_182569
GDPD1


glycerophosphodiester phosphodiesterase domain containing 1


chr2_+_120487072 0.525 NM_001184937
NM_001184939
NM_020909
EPB41L5


erythrocyte membrane protein band 4.1 like 5


chr8_+_70567634 0.525 SULF1
sulfatase 1
chr10_-_90601655 0.524 NM_144590
ANKRD22
ankyrin repeat domain 22
chr2_+_120487076 0.523 NM_001184938
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chrX_+_146801142 0.523 NM_001185075
NM_001185076
NM_001185081
NM_001185082
NM_002024
FMR1




fragile X mental retardation 1




chr21_+_29593098 0.522 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr17_+_38916895 0.521 DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr5_+_137701122 0.516 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr8_-_13018123 0.516 NM_001164271
DLC1
deleted in liver cancer 1
chr17_+_38916758 0.515 NM_004941
DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr21_+_29593088 0.514 NM_001186
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chrX_+_146801236 0.511 FMR1
fragile X mental retardation 1
chr7_+_116238309 0.510 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr21_+_29592984 0.510 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr5_+_137701601 0.507 NM_016605
FAM53C
family with sequence similarity 53, member C
chr8_+_21833111 0.507 NM_015024
XPO7
exportin 7
chr20_-_1257809 0.507 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr6_-_50039776 0.507 NM_001037499
DEFB114
defensin, beta 114
chr1_+_87569959 0.505 LMO4
LIM domain only 4
chr11_-_46572160 0.500 AMBRA1
autophagy/beclin-1 regulator 1
chr6_-_33862690 0.499 NM_001143944
LEMD2
LEM domain containing 2
chr20_-_33783409 0.497 RBM39
RNA binding motif protein 39
chr2_-_177210904 0.496 LOC375295
hypothetical LOC375295
chr6_-_105734535 0.493 NM_022361
POPDC3
popeye domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 2.03e-02 GO:0048519 negative regulation of biological process
1.40 2.76e-02 GO:0048523 negative regulation of cellular process
1.79 2.88e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.66 2.89e-02 GO:0006351 transcription, DNA-dependent
1.61 3.96e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.33 1.23e-02 GO:0045095 keratin filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 1.30e-02 GO:0005515 protein binding
1.70 1.88e-02 GO:0043565 sequence-specific DNA binding
1.56 2.55e-02 GO:0001071 nucleic acid binding transcription factor activity
1.56 2.55e-02 GO:0003700 sequence-specific DNA binding transcription factor activity